Cd47-sirpα controls adcc killing of primary t cells by pmn through a combination of trogocytosis and nadph oxidase activation

HIGHLIGHTS

• who: Franu00e7oise Gondois-Rey and collaborators from the Italy Institut Paoli-Calmettes, Aix Marseille University UM105, Marseille, France, Integrated Chemical and Structural Biology have published the research: CD47-SIRPu03b1 Controls ADCC Killing of Primary T Cells by PMN Through a Combination of Trogocytosis and NADPH Oxidase Activation, in the Journal: (JOURNAL)
• what: Trogocytosis at low ratios of PMN to CLL-B cells opsonized with anti-CD20 mAbs does not induce significant death unless SIRPa is blocked allowing activation of NADPH oxidase and strong killing, as the authors show here for ratios between 3 and 0 . . .
  

   

  

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