HIGHLIGHTS
- who: Ece Somuncular from the Karolinska Institute Uppsala University, Boston, MA, USA have published the Article: CD49b identifies functionally and epigenetically distinct subsets of lineage-biased hematopoietic stem cells, in the Journal: (JOURNAL) of July/12,/2022
- what: The authors demonstrate that CD49b subdivides the most primitive HSC compartment into functionally distinct subtypes: CD49b HSCs are highly enriched for myeloid-biased and the most durable cells while CD49b+ HSCs are enriched for multipotent cells with lymphoid bias and reduced self-renewal ability. The authors show that the contradictory findings could partly be explained by the . . .
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