Cd95l inhibition impacts gemcitabine-mediated effectsand non-apoptotic signaling of tnf- and trail in pancreatic tumor cells

HIGHLIGHTS

  • who: Khalid Rashid et al. from the Institute for Experimental Cancer Research, University Medical Centre Schleswig-Holstein (UKSH) have published the paper: CD95L Inhibition Impacts Gemcitabine-Mediated Effectsand Non-Apoptotic Signaling of TNF- and TRAIL in Pancreatic Tumor Cells, in the Journal: Cancers 2021, 5458 of 24/09/2021
  • what: The authors show that gemcitabine stimulates the expression of proinflammatory cytokines such as IL6 and IL8 under the influence of the CD95/CD95L system and the pharmacological inhibitor sCD95Fc substantially reduced the expression in two cell lines PancTuI-luc and A818-4. In Supplementary Figure . . .

     

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