Cdk2 strengthens the intra-s checkpoint and counteracts cell cycle exit induced by dna damage

HIGHLIGHTS

• who: Katarina Baamp#x0010D and eviamp#x00107 from the IGMM, CNRS, UnivMontpellier, Montpellier, France. MRI-CRBM, CNRS, Univ. Montpellier, Montpellier, France. have published the research work: Cdk2 strengthens the intra-S checkpoint and counteracts cell cycle exit induced by DNA damage, in the Journal: Scientific Reports Scientific Reports of 30/06/2016
• what: The authors show that independently of p53 status Cdk2 stimulates the ATR/Chk1 pathway and is required for an efficient DNA replication checkpoint response. Cdk2 knockdown leads to down-regulation of Cdk6 which the authors show is a non-redundant pRb kinase . . .
  

   

  

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