Cdk4/6 initiates rb inactivation and cdk2 activity coordinates cell-cycle commitment and g1/s transition

HIGHLIGHTS

• who: Sungsoo Kim from the DepartmentColumbia University have published the paper: CDK4/6 initiates Rb inactivation and CDK2 activity coordinates cell-cycle commitment and G1/S transition, in the Journal: Scientific Reports Scientific Reports
• what: The studies show that CDK4/6 activity initiates E2F activation, and CDK2 activity coordinates the timing of CDK2-Rb feedback and DNA replication in both mitogen-starved and cycling cells (Fig 5H,I). The study shows that high CDK2 activity is required to initiate CDK2-Rb positive feedback and consequently CDK4/6-indendent cell-cycle progression before promoting DNA replication . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.