Cdkn2aip is critical for spermiogenesis and germ cell development

HIGHLIGHTS

• who: Yuming Cao from the By co-injecting sgRNA and Cas, mRNA into fertilized eggs of C BL/, mice, mouse model with a, base deletion was generatedThe founders were genotyped by PCR followed by DNA sequencing analysis. Intercrossing of Cdkn2aip heterozygous mice yielded healthy offspring at Mendelian ratios. The use of mice was approved by the Animal Ethics Committee of the School of Medicine, Wuhan University. All animal care protocols and experiments were reviewed and approved by the Animal Use Committee of the School of Medicine, Wuhan University. Histological analysis have published the research: CDKN2AIP is critical . . .
  

   

  

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