Cell-based receptor discovery identifies host factors specifically targeted by the sars cov-2 spike

HIGHLIGHTS

• who: Bushra Husain from the AG, Portfolio and Assays group, Cologne, Germany have published the research work: Cell-based receptor discovery identifies host factors specifically targeted by the SARS CoV-2 spike, in the Journal: (JOURNAL) of 22/Nov/2021
• what: The authors demonstrate the applicability of this cell-based platform to characterize cell surface interactomes for diverse proteins including the immune receptor B7-H3/CD276 or the secreted factor GDF15. Surprisingly using spike pseudotyped particles as a surrogate to study viral entry the authors show that CNTN1 enhances ACE2dependent infection. One of the most . . .
  

   

  

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