Cell cluster sorting in automated differentiation of patient-speci c induced pluripotent stem cells towards blood cells

HIGHLIGHTS

SUMMARY

    The processes of iPS cell reprogramming, maintenance, and differentiation are costly and require constant supervision and cell quality assessment by highly trained personnel (Chen et_al, 2014; Niessing et_al, 2021). Manual handling introduces financial and temporal obstacles that limit large scale iPS cell application (Soares et_al, 2014; Niessing et_al, 2021). Automation of distinct steps and integrated systems of iPS cell generation, culture and differentiation have been previously described (Marx et_al, 2013; Elanzew et_al, 2015; Elanzew et_al, 2020; Konagaya et_al, 2015; Paull et_al, 2015; Coston et_al, 2020; Dhingra et_al, 2020). Human iPS cells harbor the potential . . .

     

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