Cell-free, high-density lipoprotein–specific phospholipid efflux assay predicts incident cardiovascular disease

SUMMARY

The Journal of Clinical Investigation prevalent CAD than HDL-C concentrations and is inversely associated with future CAD events. Cell-free assays that monitor fluorescent cholesterol uptake capacity of HDL have been developed as potential CAD 2 biomarkers. The authors used calcium silicate hydrate crystals labeled with fluorescence-tagged phosphatidylethanolamine as artificial lipid-donor particles to develop a high-throughput cell-free, HDL-specific phospholipid efflux assay (HDL-SPE) that measures plasma HDL-associated lipid fluorescence in the supernatant and is suitable for automation. The authors also compared the new HDL-SPE assay with cell-based cholesterol . . .

 



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