Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival

HIGHLIGHTS

• who: Xi Lu from the Uppsala University have published the article: Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show a cross-species epigenome analysis where the chromatin accessibility landscape of 9 mGSC cultures of defined developmental origin and 60 IDH wt hGSC cultures are analyzed with high-sensitivity ATAC-seq24. From hereon the authors focus mainly on the ATAC50 classification. The authors show the power of a chromatin accessibility-based functional classification of GSCs. All . . .
  

   

  

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