HIGHLIGHTS
- who: Michel M. Ouellette and colleagues from the Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA have published the Article: Cell Signaling Pathways That Promote Radioresistance of Cancer Cells, in the Journal: Diagnostics 2022, 656 of /2022/
- what: The studies have revealed the role of Rac1 in promoting the survival of breast and pancreatic cancer cells responding to IR exposure . The studies demonstrate that BRCA1 protein expression is required for the IR-induced activation of ERK1/2 signaling in breast cancer cells, and conversely, ERK1/2 activity supports the protein stability . . .
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