HIGHLIGHTS
- who: Elsa Ghirardini from the (UNIVERSITY) have published the research: Cell-specific vulnerability to metabolic failure: the crucial role of parvalbumin expressing neurons in creatine transporter deficiency, in the Journal: (JOURNAL)
- what: The authors generated an extensive transcriptomic profile of CTD showing that Cr deficiency causes perturbations of gene expression in excitatory neurons inhibitory cells and oligodendrocytes which result in remodeling of circuit excitability and synaptic wiring. In this framework, the authors focused on the high-energy-requiring P u00ad V+ GABAergic interneurons, demonstrating that this cellular population crucially contributes to the pathogenesis of CTD . . .
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