Cell surface targeting of pregnancy-associated plasma protein a proteolytic activity

HIGHLIGHTS

• who: Lisbeth S. Laursen from the proMBP GAG over binding to the binding site of the PAPP-A subunitOf particular importance, demonstrating that the GAG of proMBP inhibits adhesion, treatment of the PAPPA䡠proMBP complex with heparinase restored cell surface binding (Fig. A), whereas binding of uncomplexed PAPP-A was not affected (Fig. B). Thus, PAPP-A, still part of the disulfidebound PAPP-A䡠proMBP complex, was able to bind to the cell surface after removal of the proMBP GAG. The activities of IGF are antagonized by IGFBP-4, whose effect is abrogated when cleaved by PAPP . . .
  

   

  

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