HIGHLIGHTS
SUMMARY
Lung cancers are broadly divided into two main histological groups: NSCLC, which accounts for 80-85% of all lung cancer cases, and SCLC, consisting of 10-15%. Identifying new methods for early-stage lung cancer detection is a central focus of cancer research. In this regard, understanding the alterations in the lung tumor microenvironment (TME) throughout the early stages of cancer evolution could be a viable avenue for biomarker discovery. TP53 is the most important tumor suppressor gene and is the target of multiple mutations early in lung cancer tumorigenesis, its alterations being present . . .
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