Cellular sialoglycans are differentially required for endosomal and cell-surface entry of sars-cov-2 in lung cell lines

HIGHLIGHTS

• What: The authors used genetic and enzymatic approaches to deplete sialic acid from cell surfaces and compared the requirement for sialoglycans during endosomal and cell-surface CoV entry using lentiviral particles pseudotyped with the spike proteins of different sarbecoviruses. The authors show that entry of SARS-CoV-1 WIV1-CoV and WIV16-CoV like the SARS-CoV-2 omicron variant depends on endosomal cathepsins and requires cellular sialoglycans for entry. This study provides new insight into the roles of cellular sialoglycans during sarbecovirus entry and contributes to understanding the entry processes of recently emerged and pre-emergent . . .
  

   

  

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