HIGHLIGHTS
- who: REPORT from the Centro have published the Article: Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis, in the Journal: (JOURNAL) of 03/09/2022
- what: The authors examined centrosomes in Barrett's esophagus tumorigenesis, a wellcharacterized multistep pathway of progression, from the premalignant condition to the metastatic disease. The work shows that centrosome amplification in human tumorigenesis can occur before transformation, being repressed by p53. Patient selection and clinical samples For the purpose of this study, three cohorts of patients were selected from the Pathology Department database of Instituto Portugu . . .
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