Cerebellar neuronal dysfunction accompanies early motor symptoms in spinocerebellar ataxia type 3

HIGHLIGHTS

  • who: Cerebellar neuronal dysfunction accompanies from the (UNIVERSITY) have published the paper: Cerebellar neuronal dysfunction accompanies early motor symptoms in spinocerebellar ataxia type 3, in the Journal: (JOURNAL) of 11/02/2022
  • what: The authors show that, early in disease, the activity of neurons in the DCN of SCA3 mice was irregular, with irregular Purkinje cell activity likely to be a contributing factor.
  • how: The authors examined whether abnormal output was present in the CMVMJD135 SCA3 mouse model and if so whether it correlated with the disease onset and progression. Understanding the contributors . . .

     

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