Cetsa-based target engagement of taxanes as biomarkers for efficacy and resistance

HIGHLIGHTS

• who: Anette Langebamp#x000E4 and ck from the DepartmentTechnological University have published the paper: CETSA-based target engagement of taxanes as biomarkers for efficacy and resistance, in the Journal: Scientific Reports Scientific Reports
• what: The authors implemented different formats of tubulin-specific CETSA and used these to study taxane TE in cell lines of breast and prostate cancer as well as mouse xenografts. Using cognate pairs of sensitive and resistant cell lines the authors show that CETSA can efficiently reveal the presence of drug resistance mechanisms. Using miniaturized CETSA the authors demonstrate that TE responses . . .
  

   

  

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