Cgas/sting activation by dsdna immune complexes international

HIGHLIGHTS

• who: Wiskott-Aldrich syndrome protein and colleagues from the University Medical Autoimmunity, MedImmune LLC, Gaithersburg, Maryland, USA have published the Article: cGAS/STING activation by dsDNA immune complexes International, in the Journal: (JOURNAL) of December/12,/1987
• what: The authors show that immune complexes of self-DNA and autoantibodies (DNA-ICs) contribute to elevated IFN levels via activation of the cGAS/STING pathway of cytosolic sensing. The authors show that lack of WASp expression in DCs renders cells responsive to small doses of self-DNA in immune complex with autoantibodies (DNA-ICs), inducing activation of . . .
  

   

  

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