Cgas/sting-mediated immune_responses in pediatric high-grade glioma models

HIGHLIGHTS

• who: H et al. from the DepartmentUniversity of, Cleveland Clinic, Cleveland, Ohio, USA have published the paper: cGAS/STING-mediated immune_responses in pediatric high-grade glioma models, in the Journal: (JOURNAL)
• what: Using a syngeneic genetically engineered mouse model (GEMM) and human pHGG cells encoding H3.3-G34R the authors demonstrate that this mutation led to the downregulation of DNA repair pathways. The authors demonstrate that genetic instability resulting from improper DNA repair in G34R-mutant pHGG led to the accumulation of extrachromosomal DNA which activated the cyclic GMP-AMP synthase/ stimulator of IFN genes . . .
  

   

  

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