HIGHLIGHTS
- who: CGG repeats trigger translational and collaborators from the Department of Neurology, University of Michigan, USA, Neuroscience Graduate Program have published the article: CGG repeats trigger translational frameshifts that generate aggregation-prone chimeric proteins, in the Journal: (JOURNAL)
- what: The authors show the most abundant RAN translation product FMRpolyG is markedly less toxic when generated from a construct with a non-repetitive alternating codon sequence in place of the repeat.
SUMMARY
At CGG repeats, RAN translation occurs in all three potential reading_frames at different efficiencies and with most initiation beginning from . . .
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