HIGHLIGHTS
- who: August and collaborators from the Biophysics Institute, National Research Council (CNR), Italy Wright State University, United States have published the research: Chaperone activity of ni acid on ClC-1 chloride channel mutants causing myotonia congenita, in the Journal: (JOURNAL)
- what: The authors show that NFA reversibly blocked the ClC-1 channel when the drug was applied acutely, whereas it can act as a pharmacological chaperone after prolonged exposure. Such effects were confirmed in the current study, demonstrating that the instantaneous and steady-state current amplitudes were greatly reduced through the entire voltage range for . . .
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