Chaperone functions of the e3 ubiquitin ligase chip*

HIGHLIGHTS

• who: Meredith F.N. Rosser from the (UNIVERSITY) have published the paper: Chaperone Functions of the E3 Ubiquitin Ligase CHIP*, in the Journal: (JOURNAL) of January/18,/2007
• what: The authors report that CHIP exhibits intrinsic chaperone function that enables it to bind nonnative substrates and suppress protein aggregation.
• how: This result was puzzling because purified CHIP functions with Hsp70 to polyubiquitinate misfolded luciferase and therefore CHIP would be expected to clear denatured luciferase from the cell instead of enhancing its reactivation.
• future: In an extension of these studies CHIP⌬TPR . . .
  

   

  

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