Chaperonin tric/cct modulates the folding and activity of leukemogenic fusion oncoprotein aml1-eto*

HIGHLIGHTS

• who: Soung-Hun Roh from the (UNIVERSITY) have published the paper: Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO*, in the Journal: (JOURNAL) of February/26,/2016
• what: The authors demonstrate that AML1-ETO, the most common leukemogenic fusion_protein in AML, interacts with major components of the protein folding machinery; namely, TRiC, HSP70, and HSP90. The authors show that TRiC directly binds to AML1-ETO, thereby contributing to its folding, biogenesis, and native activity.
• how: Rather the data is consistent with the "out-of-cage" refolding model . . .
  

   

  

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