Characterisation of the otu domain deubiquitinase complement of toxoplasma gondii

HIGHLIGHTS

  • who: Christopher J Tonkin and colleagues from the Walter and Eliza Hall Institute of Medical Research, Parkville, Australia have published the research work: Characterisation of the OTU domain deubiquitinase complement of Toxoplasma gondii, in the Journal: (JOURNAL)
  • what: The authors were unable to determine substrates for TgOTUD3C or TgOTU10.
  • how: Combining prior studies and further sequence annotation the authors identified 14 OTU DUBs in Toxoplasma a main difference to previous studies was the reannotation of OTUD1 orthologues (Fig 1). As a first test for reactivity with ubiquitin the authors used Ub-propargylamine (Ub . . .

     

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