Characterization of a brain-enriched chaperone, mrj, that inhibits huntingtin aggregation and toxicity independently*

HIGHLIGHTS

• who: Jen-Zen Chuang from the (UNIVERSITY) have published the research: Characterization of a Brain-enriched Chaperone, MRJ, That Inhibits Huntingtin Aggregation and Toxicity Independently*, in the Journal: (JOURNAL) of March/12,/2002
• how: The authors showed that MRJ-(1-109) was capable of increasing Hsp70 ATPase activity by ⬃5.5-fold.

SUMMARY

Although most DnaJ-like proteins studied are ubiquitously expressed, some have restricted expression, so it is possible that some specific chaperones may affect polyglutamine aggregation in specific neurons. Tissue distribution studies showed that MRJ is highly enriched in . . .

 



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