Characterization of a family of scorpion toxins modulating ca2+-activated cl- current in vascular myocytes

HIGHLIGHTS

• who: Jean-Luc Morel and colleagues from the UnivBordeaux, CNRS, INCIA, UMR, EPHE, Bordeaux, France have published the article: Characterization of a Family of Scorpion Toxins Modulating Ca2+-Activated Cl- Current in Vascular Myocytes, in the Journal: Toxins 2022, 780 of /2022/
• what: The authors demonstrate that specific amino-acid changes by toxin synthesis, which do not alter the three-dimensional structure, could abolish toxin inhibition activity on Ca2+ -activated Cl- channels.
• how: Similar results were obtained with obtained with application of 10 nM angiotensin II inducing a transient increase in cytosolic 6 . . .
  

   

  

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