Characterization of a lung epithelium specific e-cadherin knock-out model: implications for obstructive lung pathology

HIGHLIGHTS

• who: S. Post from the Conditional, cadherin knock-out mice (Cdh1fl/fl, Cdh1tm Kem/J), backcrossed onto the C Bl/, J background were purchased from Jackson Laboratory (Bar Harbor, ME). The compound transgenic sftpc-rtTA/(tetO)7-Cre mice that express the reverse tetracycline trans-activator (rtTA) under control of the rat SFTPC promoter were kindly provided by Prof. Geoffrey Whittset. The SFTPC promoter is expressed as early as day , of gestation in epithelial cells of the primordial lung buds22, causing all lung epithelial cells to express Cre recombinase under control of the tet operator (tetO)23 . . .
  

   

  

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