Characterization of a novel sesquiterpene cyclase involved in (+)-caryolan-1-ol biosynthesis in streptomyces griseus*

HIGHLIGHTS

• who: Chiaki Nakano from the Chiaki Nakano, Sueharu Horinouchi, and Yasuo Ohnishi, From the Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo, Japan Most terpenoids have been isolated from plants and fungi and only a few from bacteria. However, an increasing number of genome sequences indicate that bacteria possess a variety of terpenoid cyclase genes. We characterized a sesquiterpene cyclase gene (SGR2079, named gcoA) found in Streptomyces griseus. When expressed in Streptomyces lividans, gcoA directed production of a sesquiterpene, isolated and determined to be (ⴙ)caryolan-1-ol . . .
  

   

  

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