Characterization of hotspot exonuclease domain mutations in the dna polymerase ε gene in endometrial cancer

HIGHLIGHTS

• who: Wenjuan Tian and collaborators from the The First Affiliated Hospital of Sun Yatsen University, China have published the article: Characterization of hotspot exonuclease domain mutations in the DNA polymerase ε gene in endometrial cancer, in the Journal: (JOURNAL)
• what: In this study, by targeted sequencing of POLE in tumor tissue samples from 138 patients with endometrial cancer, the authors identified four POLE hotspot EDMs P286R, V411L, R375Q, and P452L, among which R375Q and P452L were reported for the first time. The authors demonstrate that these hotspot EDMs are associated with favorable prognosis in patients . . .
  

   

  

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