HIGHLIGHTS
- who: March et al. from the Rostock University Medical Center, Germany have published the paper: Characterization of ligand-induced thermal stability of the human organic cation transporter 2 (OCT2), in the Journal: (JOURNAL)
- what: This approach has shown low sensitivity in the prediction of OCT2 inhibition, arguably because several ligands can inhibit OCT2-mediated transport in a non-competitive or mixed fashion (Harper and Wright, 2013) and because the ligand spatial interaction with OCT2 as well as the strength thereof is conditional to the model substrate (Keller et_al, 2019; Hormann et_al, 2020; Sutter et_al, 2021 . . .
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