Characterization of proprotein convertase subtilisin/kexin type 9 (pcsk9) trafficking reveals a novel lysosomal targeting mechanism via amyloid precursor-like protein 2 (aplp2)

HIGHLIGHTS

• who: Rachel M. DeVay from the (UNIVERSITY) have published the research: Characterization of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Trafficking Reveals a Novel Lysosomal Targeting Mechanism via Amyloid Precursor-like Protein 2 (APLP2), in the Journal: (JOURNAL) of April/12,/2013
• what: Based on the data , the authors propose a model for a lysosomal transport complex by which a soluble protein can target another protein for degradation from the luminal side of the membrane by bridging it to a lysosomally targeted transmembrane protein.

SUMMARY

The authors discovered that PCSK9 interacts . . .

 



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