Characterization of ser338 phosphorylation for raf-1 activation*

HIGHLIGHTS

• who: Mengwei Zang from the (UNIVERSITY) have published the article: Characterization of Ser338 Phosphorylation for Raf-1 Activation*, in the Journal: (JOURNAL) of November/14,/2008
• what: This study provides novel insights into the mechanism of Ser338 phosphorylation of Raf-1.
• how: Next the authors made a series of mutations to mimic or disable phosphorylation in two sets of sites Ser338 and Tyr341 the negative region between the amino-terminal regulatory and carboxyl kinase domains and Ser471/Ser494 in the activation segment and tested the impacts of phosphorylation of these sites on Raf . . .
  

   

  

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