HIGHLIGHTS
SUMMARY
With the high prevalence and poor prognosis, lung cancer is ranked as the first leading cause of cancer-related deaths worldwide, becoming a major global health problem (Miller et_al, 2019; Siegel et_al, 2019; Sung et_al, 2021). The emergence of checkpoint blockade immunotherapy (Pardoll, 2012; Topalian et_al, 2015) has significantly improved the strategies of LUAD. The effects of ICIs are not only driven by genetic and epigenetic alterations in tumor cells, but the tumor microenvironment (TME) has also been reported to be a crucial regulator in tumorigenesis (Dejima et_al, 2021; Ye et_al, 2022), development, metastasis . . .
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