Characterization of wise protein and its molecular mechanism to interact with both wnt and bmp signals*

HIGHLIGHTS

  • who: Katherine B. Lintern from the (UNIVERSITY) have published the paper: Characterization of Wise Protein and Its Molecular Mechanism to Interact with both Wnt and BMP Signals*, in the Journal: (JOURNAL) of August/21,/2009

SUMMARY

    Wise was found to bind to the Wnt co-receptor, LRP6, sharing the binding domain with Wnt ligands. A three-dimensional structural model was built of the chick Wise sequence from residue 68 to 186 based on the human chorionic gonadotropin structure (Protein Data Bank code 1HCN) extracted from the Protein Data Bank. The BMP4 construct is . . .

     

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