Characterizing the composition of ipsc derived cells from bulk transcriptomics data with cellmap

HIGHLIGHTS

  • who: Zhengyu Ouyang from the Inc have published the paper: Characterizing the composition of iPSC derived cells from bulk transcriptomics data with CellMap, in the Journal: Scientific Reports Scientific Reports
  • how: Similar observations were made previously by Patrick et_al19 Based on their analysis and the technical variability of snRNA-seq data the authors anticipate the IHC proportions to be closer to the true composition. Very similar observations were made by Avila Cobos et_al when testing the effect of removing cell types from the reference matrix in multiple deconvolution u00adalgorithms5.

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