Characterizing the evolutionary dynamics of cancer proliferation in single-cell clones with sprinter

HIGHLIGHTS

• Who: Olivia Lucas from the (UNIVERSITY) have published the research work: Characterizing the evolutionary dynamics of cancer proliferation in single-cell clones with SPRINTER, in the Journal: (JOURNAL) of 11/09/2023
• How: Because ctDNA frequency is not only influenced by proliferation but also by clone volume (that is number of cells) the authors calculated a ctDNA shedding index at surgery for each clone as the difference between ctDNA and primary tumor frequencies of SNVs with the latter estimated based on either this single-cell analysis or previous bulk analyses14 (Methods). The results are consistent . . .
  

   

  

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