Chemerin alleviates the placental oxidative stress and improves fetal overgrowth of gestational diabetes mellitus mice induced by high fat diet

HIGHLIGHTS

• What: The authors analyzed the discrepancy of placental oxidative stress between GDM and normoglycaemic pregnant women, and assessed the contributions of chemerin in enhancing ROS clearance and augmenting total antioxidant capacity (T-AOC). Reassuringly, this study provided the evidence, specifically from in_vivo assays, that chemerin might modulate the insulin signaling by up-regulating the expression of AKT in placenta of GDM mice. The authors found that the body weight of HFD mice offspring at 1 week and 2 weeks of age was remarkably increased compared with that of the chow group, which might be related to the . . .
  

   

  

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