Chemical modifications of adenine base editor mrna and guide rna expand its application scope

HIGHLIGHTS

• who: Tingting Jiang from the Therapeutics Institute University of, Worcester, MA, TriLink BioTechnologies, San Diego, CA, USA. have published the paper: Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors demonstrate that this RNAbased system mediates robust editing in hard-to-transfect cystic fibrosis bronchial epithelial_cells. The authors demonstrate that uridine depletion and 5-methoxyuridine modification is critical for the stable expression of ABE mRNA. The authors provide the first report on delivery of RNA-encoded ABE to effectively correct . . .
  

   

  

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