Chemically defined and small molecules-based generation of sinoatrial node-like cells

HIGHLIGHTS

  • who: Xiaojie Hou from the Department of Cardiovascular Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, China have published the paper: Chemically defined and small molecules-based generation of sinoatrial node-like cells, in the Journal: (JOURNAL)
  • what: The authors aimed to establish a differentiation methods to generate SANLCs effectively and stably. The authors provide an optimized and protocol to generate SANLCs by combined modulation of WNT RA and FGF pathways and metabolic selection by lactate enrichment and glucose starvation. This study proposes a method for the efficient and reproducible generation of SANLCs that display . . .

     

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