Chemogenetic attenuation of cortical seizures in nonhuman primates

HIGHLIGHTS

• who: Naohisa Miyakawa from the (UNIVERSITY) have published the research work: Chemogenetic attenuation of cortical seizures in nonhuman primates, in the Journal: (JOURNAL)
• what: Third, this study demonstrated chemogenetic seizure attenuation but not its complete cessation, indicating that there is room for improvement. This study demonstrated for the first time in NHPs that inhibitory DREADD hM4Di combined with its actuator DCZ is capable of attenuating cortical seizures.
• how: The authors examined the efficacy of a chemogenetic tool-designer receptors exclusively activated by designer drugs (DREADDs)-for treating focal seizure in a nonhuman primate . . .
  

   

  

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