Chemoselective oxidation of isoxazolidines with ruthenium tetroxide: a successful intertwining of combined theoretical and experimental data

HIGHLIGHTS

  • who: Laura Legnani et al. from the 0126, Italy have published the research: Chemoselective Oxidation of Isoxazolidines with Ruthenium Tetroxide: A Successful Intertwining of Combined Theoretical and Experimental Data, in the Journal: Molecules 2022, 5390 of /2022/
  • what: The authors report a computational mechanistic study of RuO4 -catalyzed oxidation of differently N-substituted isoxazolidines Attention was focused on the endo/exo oxidation selectivity.

SUMMARY

    For the exo pathway, due to the presence of the stereogenic center at position 5 of the isoxazolidine, and the formation of a second stereogenic center for . . .

     

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