Chickpea ncr13 disulfide cross-linking variants exhibit profound differences in antifungal activity and modes of action

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  • What: The work was supported by the National Science Foundation grant IOS2037981 and the National Institute of Food and Agriculture GRANT13515963 to D.S and K.C. Salaries of D. C.Z. and G. were partly funded by the NIFA Grant 13515963 and NSF grant IOS2037981. The authors show that a highly cationic chickpea NCR13 peptide expressed in Pichia pastoris forms two structurally unique disulfide variants despite having an identical amino_acid sequence. For NCR13_PFV2, this approach showed that the disulfide bonds were C4-C10, C15-C30, and PLOS Pathogens | https://doi.org/10.1371/journal.ppat . The . . .

     

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