Chiral aldehyde-nickel dual catalysis enables asymmetric î±âˆ’propargylation of amino acids and stereodivergent synthesis of np25302

HIGHLIGHTS

• who: Fang Zhu from the (UNIVERSITY) have published the article: Chiral aldehyde-nickel dual catalysis enables asymmetric u00ceu00b1u00e2u02c6u2019propargylation of amino acids and stereodivergent synthesis of NP25302, in the Journal: (JOURNAL) of 10/08/2022
• what: The authors rational design a chiral aldehyde/nickel combining catalytic system, which can efficiently promote the direct asymmetric u03b1-propargylation reaction of N-unprotected amino_acid esters with propargyl alcohol derivatives.
• how: These results indicated that this chiral aldehyde/ nickel combining catalytic system has unique properties in achieving this type of organic transformation. Indicated that the yield and ee . . .
  

   

  

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