Chlorpromazine, a clinically approved drug, inhibits sars-cov-2 nucleocapsid-mediated induction of il-6 in human monocytes

HIGHLIGHTS

  • who: Iwona Karwaciak and colleagues from the Laboratory of Epigenetics, Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland have published the paper: Chlorpromazine, a Clinically Approved Drug, Inhibits SARS-CoV-2 Nucleocapsid-Mediated Induction of IL-6 in Human Monocytes, in the Journal: Molecules 2022, 3651 of 27/04/2022
  • what: The authors show that inhibits the expression and secretion of IL-6 by monocytes activated by SARS-CoV-2 virus nucleocapsid protein and affects the activity of NF-κB and MEK/ERK signaling. The authors show that the antipsychotic drug chlorpromazine .
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