Cholesterol-dependent generation of a seeding amyloid β-protein in cell culture*

HIGHLIGHTS

• who: Tetsuya Mizuno from the (UNIVERSITY) have published the Article: Cholesterol-dependent Generation of a Seeding Amyloid β-Protein in Cell Culture*, in the Journal: (JOURNAL) of December/14,/1998
• what: The authors report that a seeding Ab, which catalyzes the fibrillogenesis of soluble Ab, is generated from the apically missorted amyloid precursor protein in cultured epithelial_cells. To exclude the possibility of a different Ab species being extracted in the experiment of mass spectrometry because of a difference in the used extracting buffer, the authors performed Western blotting analysis of the immunoprecipitates extracted with trifluoroacetic acid . . .
  

   

  

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