Cholesterol stationary phase in the separation and identification of sirna impurities by two-dimensional liquid chromatography-mass spectrometry

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  • who: Sylwia Studziu0144ska et al. from the Chair of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University in Torunu0301, Gagarin Str, Torunu0301, Poland have published the paper: Cholesterol Stationary Phase in the Separation and Identification of siRNA Impurities by Two-Dimensional Liquid Chromatography-Mass Spectrometry, in the Journal: (JOURNAL)
  • what: The aim of this research was to develop a simple and efficient ion-pair reagent-free chromatographic method for the separation and qualitative determination of oligonucleotide impurities exemplified by synthesis of raw products of the two single strands of patisiran siRNA. The aim . . .

     

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