Cholinergic basal forebrain nucleus of meynert regulates chronic pain-like behavior via modulation of the prelimbic cortex

HIGHLIGHTS

• who: Manfred J. Oswald from the Surgical procedures Mice were deeply anaesthetized by intraperitoneal injection of fentanyl (, mg/kg), medetomidine hydrochloride (0., mg/kg), midazolam (, mg/kg). Lidocaine (10%) was applied to the surface of the skin, and a small hole was drilled above the region of interest. In vivo delivery of recombinant adeno-associated virus (rAAVs) was performed by stereotactic injections. The NBM coordinates used relative to bregma were posteriormm, lateral, ., mm, at a depth ofmm from the pia. rAAV2-EF1a-DIO-hChR2(H R)-EYFP (University of North Carolina Vector Core, USA) virus (, nl) was . . .
  

   

  

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