Cholinergic rest-g9a gene repression through hmgb1-tlr4 neuroimmune signaling regulates basal forebrain cholinergic neuron phenotype

HIGHLIGHTS

• who: Ryan P. Vetreno from the Bielefeld University, Germany have published the article: Cholinergic REST-G9a gene repression through HMGB1-TLR4 neuroimmune signaling regulates basal forebrain cholinergic neuron phenotype, in the Journal: (JOURNAL)
• what: The authors report that H3K9me2 occupancy at the CpG island located within the Chat gene was increased approximately 1.7-fold in LPS-treated FSCs ( =2.2, p and amp;lt; 0.05; Figure 4A), but no change was observed at the Chat promoter or Lhx8 promoter. The authors report here reversal of ChAT + IR neuron loss with the G9a inhibitor . . .
  

   

  

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