Chondroitin sulfate proteoglycans prevent immune cell phenotypic conversion and inflammation resolution via tlr4 in rodent models of spinal cord injury

HIGHLIGHTS

• who: Isaac Francos-Quijorna from the Centre University of have published the research: Chondroitin sulfate proteoglycans prevent immune cell phenotypic conversion and inflammation resolution via TLR4 in rodent models of spinal cord injury, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors demonstrate that CSPGs have prominent immunomodulatory effects which impede multiple aspects of the resolution of inflammation after SCI. Using TLR4 inhibitors and TLR4 knockout mice the authors demonstrate that activation of TLR4 signalling by CSPGs prevents macrophages and microglia from converting to a pro-resolution phenotype. The authors propose this as a . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.